Evaluation of HER2/neu in Ovarian Cancer: A Systematic Analysis of Observational Study in a Tertiary Care Centre in Northern India

Abstract

Introduction: Ovarian cancer accounts for 6% of all cancers in the female and is the fifth most common form of cancer in women which is caused by amplification of HER2/neu gene and it is widely studied most of the cancer but in gynecologic neoplasms it not well established biomarkerhence the study is carried out to analyse incidence of ovarian carcinoma in the local population and analysed relationship of HER2/neu positive cases with the histological type of ovarian tumour. Materials and Methods:The present study was an observational study. A total of 30 cases were studied and systematically evaluated the HER2/neu reactions by histopathological and immunohistochemical study done in Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh. Result: Majority of the cases of ovarian carcinomas fell in the age group of 30-50 years with premenopausal age group followed by menopausal age group. Surface epithelial tumours were the most frequently encountered carcinomas in the present study in 50% of the cases followed by granulosa cell tumour in 20% of the cases. Conclusion: Present study emphasized the HER2/neu reactivity in ovarian carcinomas. 76.7% of the cases were negative for HER2/neu. Positivity was noted in 23.3% cases.