A Retrospective and Prospective Study on Fine Needle Aspiration Cytology and Histopathological Correlation in Diagnosis of Salivary Gland Lesions

Abstract

Introduction: Salivary gland neoplasm accounts for 2 to 6.5%
of all head and neck neoplasms. The purpose of conducting
the study is to perceive the spectrum of various salivary
gland lesions and correlates it to the fine needle aspiration
cytology (FNAC) diagnosis with absolute sensitivity, specificity,
diagnostic accuracy, the positive and negative predictive value
of FNAC of salivary gland swellings
Materials and methods: The study was conducted in the
Department of Pathology in association with the Department
of ENT, Shri Ram Murti Smarak Institute of Medical Sciences,
Bareilly, UP and it includes a total of 140 cases. Study designing
has been done to compare results of preoperative FNAC
findings with final histopathological diagnosis, retrospectively
and prospectively.
Results: The majority of the cases of salivary gland lesions
(27.86%) fall in the 4th decade and 62.15% of males were
predominantly affected with pain and swelling as chief
complaints and for a time duration of <6 months with 71 cases.
It was found that 69.20% parotid gland was the most common
presentation site. Out of 140 cases, 70 cases of benign tumors
were the most frequent type, followed by non-neoplastic lesions
with 38 cases and the least cases of malignant tumors, with
32 cases reported. Out of a total of 102 tumors most common
benign condition was 52.90% of pleomorphic adenoma
and the most common malignant condition was 10.70% of
mucoepidermoid carcinoma.
Conclusion: Fifty cases after diagnosis on fine needle
aspiration cytology were sent for histopathology with 20 true
positive cases, 22 true negative cases, 1 false positive, and
7 false negative cases. The following values were calculated
using the Gallen and Gambino method – Sensitivity – 74.07%,
specificity–95.60%, diagnostic accuracy – 84%, positive
predictive value–95.23% (PPV) and negative predictive value
–75.86% (NPV).